Identification of two novel primate-specific genes in DSCR

Kunihiko Takamatsu, Kohei Maekawa, Takushi Togashi, Dong Kug Choi, Yutaka Suzuki, Todd D. Taylor, Atsushi Toyoda, Sumio Sugano, Asao Fujiyama, Masahira Hattori, Yoshiyuki Sakaki, Tadayuki Takeda

研究成果: Article

14 引用 (Scopus)

抜粋

We recently helped to complete the sequence of human chromosome 21 at a very high level of accuracy. Using this sequence we identified two novel genes, designated DSCR9 and DSCR10, in the so-called Down Syndrome Critical Region (DSCR) by computational gene prediction and subsequent cDNA cloning. Both DSCR9 and DSCR10 are expressed preferentially in testis and encode functionally unknown proteins with 149 and 87 amino acid residues, respectively. Zoo blot analysis suggested that both genes are exclusive to primate genomes such as chimpanzee, gorilla, orangutan, crab-eating monkey and African green monkey but are not present in other non-primate mammals including mouse, dog, cat, and chicken. Comparative genomic sequence analysis of DSCR9 and DSCR10 with the corresponding mouse syntenic region confirmed the lack of these genes in the mouse. These results strongly suggest that DSCR9 and DSCR10 have emerged as a new class of gene in the primate lineage during evolution.

元の言語English
ページ(範囲)89-97
ページ数9
ジャーナルDNA Research
9
発行部数3
DOI
出版物ステータスPublished - 2002
外部発表Yes

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

フィンガープリント Identification of two novel primate-specific genes in DSCR' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takamatsu, K., Maekawa, K., Togashi, T., Choi, D. K., Suzuki, Y., Taylor, T. D., Toyoda, A., Sugano, S., Fujiyama, A., Hattori, M., Sakaki, Y., & Takeda, T. (2002). Identification of two novel primate-specific genes in DSCR. DNA Research, 9(3), 89-97. https://doi.org/10.1093/dnares/9.3.89