Identification of zinc finger transcription factor EGR2 as a novel acetylated protein

Kota Noritsugu, Akihiro Ito, Yoichi Nakao, Minoru Yoshida

研究成果: Article査読

6 被引用数 (Scopus)

抄録

EGR2 is a zinc finger transcription factor that regulates myelination in the peripheral nervous system and T cell anergy. The transcriptional activity of EGR2 is known to be regulated by its co-activators and/or co-repressors. Although the activity of transcription factors is generally regulated not only by interactions with co-regulators but also posttranslational modifications including acetylation, little is known about posttranslational modifications of EGR2. Here we show that EGR2 is a novel acetylated protein. Through immunoblotting analyses using an antibody that specifically recognizes the acetylated form of EGR2, CBP and p300 were identified as acetyltransferases, while HDAC6, 10 and SIRT1 were identified as deacetylases of EGR2. Although the NuRD complex containing HDAC1 and HDAC2 is known to associate with EGR2, the present study suggests that acetylation of EGR2 is regulated independently of NuRD.

本文言語English
ページ(範囲)455-459
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
489
4
DOI
出版ステータスPublished - 2017 8 5

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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