Imaging of Myocardial Fibrosis in Patients with End-Stage Renal Disease: Current Limitations and Future Possibilities

M. P.M. Graham-Brown*, A. S. Patel, D. J. Stensel, D. S. March, A. M. Marsh, J. McAdam, G. P. McCann, J. O. Burton

*この研究の対応する著者

研究成果: Review article査読

21 被引用数 (Scopus)

抄録

Cardiovascular disease in patients with end-stage renal disease (ESRD) is driven by a different set of processes than in the general population. These processes lead to pathological changes in cardiac structure and function that include the development of left ventricular hypertrophy and left ventricular dilatation and the development of myocardial fibrosis. Reduction in left ventricular hypertrophy has been the established goal of many interventional trials in patients with chronic kidney disease, but a recent systematic review has questioned whether reduction of left ventricular hypertrophy improves cardiovascular mortality as previously thought. The development of novel imaging biomarkers that link to cardiovascular outcomes and that are specific to the disease processes in ESRD is therefore required. Postmortem studies of patients with ESRD on hemodialysis have shown that the extent of myocardial fibrosis is strongly linked to cardiovascular death and accurate imaging of myocardial fibrosis would be an attractive target as an imaging biomarker. In this article we will discuss the current imaging methods available to measure myocardial fibrosis in patients with ESRD, the reliability of the techniques, specific challenges and important limitations in patients with ESRD, and how to further develop the techniques we have so they are sufficiently robust for use in future clinical trials.

本文言語English
論文番号5453606
ジャーナルBioMed Research International
2017
DOI
出版ステータスPublished - 2017
外部発表はい

ASJC Scopus subject areas

  • 免疫学および微生物学(全般)
  • 生化学、遺伝学、分子生物学(全般)

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