Imidazole- and imidazolium-containing polymers for biology and material science applications

Emily B. Anderson, Timothy Edward Long*

*この研究の対応する著者

研究成果: Review article査読

262 被引用数 (Scopus)

抄録

The imidazole ring is ubiquitous in nature and imidazole functionality plays a critical role in many structures within the human body, notably as histamine and histadine. Imidazoles offer many biophysical interactions including their ability to hydrogen bond with drugs and proteins. In contrast, imidazolium salts have lost their strong hydrogen-bonding ability through alkylation of both nitrogens, but they are able to aggregate electrostatically. Imidazolium salts are used to extract metal ions from aqueous solutions, dissolve carbohydrates, create polyelectrolyte brushes on surfaces, coat metal nanoparticles, provide antimicrobial action, and create oriented liquid crystals. Bioactive applications include imidazolium hydrogels, antiarrhythmics, and anti-metastic agents. This review will describe the synthesis and design of imidazole derivatives and imidazolium-containing polymers as bioactive materials. Imidazole-based polymers readily associate with biological molecules through hydrogen-bonding, and imidazolium analogs offer electrostatic interactions, aggregation, and self-assembly. Design of novel imidazole- and imidazolium-based macromolecules remains as an exciting and emerging field.

本文言語English
ページ(範囲)2447-2454
ページ数8
ジャーナルPolymer
51
12
DOI
出版ステータスPublished - 2010 5 1
外部発表はい

ASJC Scopus subject areas

  • 有機化学
  • ポリマーおよびプラスチック

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