Implications of protein degradation in aging

Sataro Goto*, Ryoya Takahashi, Atsushi Kumiyama, Zsolt Radák, Toshiaki Hayashi, Masaki Takenouchi, Ryoichi Abe

*この研究の対応する著者

研究成果: Article査読

68 被引用数 (Scopus)

抄録

Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration of cellular functions and eventually result in increased probability of death. Metabolic turnover of proteins thus plays an essential role in maintaining the life of an organism. In this article we summarize our current knowledge on age-related changes in protein turnover with special reference to degradation. Increase in half-life of proteins with advancing age is well documented. Qualitative rather than quantitative changes of proteasomes appear to be responsible for this change. Dietary restriction and moderate long-term exercise seem to restore higher proteasome activity and turnover rate of proteins in aged animals.

本文言語English
ページ(範囲)54-64
ページ数11
ジャーナルAnnals of the New York Academy of Sciences
928
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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