Improvement of transcutaneous fluorescent images with a depth-dependent point-spread function

Koichi Shimizu, Koji Tochio, Yuji Kato

研究成果: Article査読

36 被引用数 (Scopus)

抄録

The point-spread function (PSF) for transcutaneous fluorescent imaging was obtained as an analytical solution in a closed form. It is applicable to cases in which the optical property of the image-blurring turbid medium is considered to be fairly homogeneous. We proposed a technique to improve a transcutaneous image by using depth-dependent PSF. Contrast of the fluorescent image was improved for depths of 1-15 mm in a scattering medium (μs′ = 1/mm). The visible depth was more than doubled with this technique. An experiment with a rat demonstrated considerable improvement of a transcutaneous image of the cerebral vein at a specified depth. The spread image of the heart was reduced to the correct size by use of the PSF with the actual depth of the heart.

本文言語English
ページ(範囲)2154-2161
ページ数8
ジャーナルApplied Optics
44
11
DOI
出版ステータスPublished - 2005 4 10
外部発表はい

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

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