In situ telomerase activity in pleural effusions: A promising marker for malignancy

Annika Dejmek*, Naoyuki Yahata, Kazuma Ohyashiki, Yoshiro Ebihara, Masatoshi Kakihana, Takashi Hirano, Norihiko Kawate, Harubumi Kato

*この研究の対応する著者

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Telomerase activity in 16 pleural effusions was studied using an in situ telomerase repeat amplification protocol (TRAP) assay on cytospin preparations. Six of nine cytologically malignant specimens contained telomerase-positive cells (67%), and in two further specimens, suspicious positive cells were seen. Two of four atypical specimens contained telomerase-positive cells, whereas two benign cases were telomerase-negative. No mesothelial cells showed telomerase reactivity. Thus, telomerase activity was specific for malignancy and it was always found only in malignant cells. The results suggest that telomerase activity measured with this in situ method can be a valuable complement in the assessment of malignancy in pleural effusions. Diagn. Cytopathol. 2001;24: 11-15.

本文言語English
ページ(範囲)11-15
ページ数5
ジャーナルDiagnostic cytopathology
24
1
DOI
出版ステータスPublished - 2001 1月 16
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学

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