抄録
Telomerase activity in 16 pleural effusions was studied using an in situ telomerase repeat amplification protocol (TRAP) assay on cytospin preparations. Six of nine cytologically malignant specimens contained telomerase-positive cells (67%), and in two further specimens, suspicious positive cells were seen. Two of four atypical specimens contained telomerase-positive cells, whereas two benign cases were telomerase-negative. No mesothelial cells showed telomerase reactivity. Thus, telomerase activity was specific for malignancy and it was always found only in malignant cells. The results suggest that telomerase activity measured with this in situ method can be a valuable complement in the assessment of malignancy in pleural effusions. Diagn. Cytopathol. 2001;24: 11-15.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 11-15 |
| ページ数 | 5 |
| ジャーナル | Diagnostic Cytopathology |
| 巻 | 24 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | Published - 2001 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Anatomy
これを引用
In situ telomerase activity in pleural effusions : A promising marker for malignancy. / Dejmek, Annika; Yahata, Naoyuki; Ohyashiki, Kazuma; Ebihara, Yoshiro; Kakihana, Masatoshi; Hirano, Takashi; Kawate, Norihiko; Kato, Harubumi.
：: Diagnostic Cytopathology, 巻 24, 番号 1, 2001, p. 11-15.研究成果: Article
}
TY - JOUR
T1 - In situ telomerase activity in pleural effusions
T2 - A promising marker for malignancy
AU - Dejmek, Annika
AU - Yahata, Naoyuki
AU - Ohyashiki, Kazuma
AU - Ebihara, Yoshiro
AU - Kakihana, Masatoshi
AU - Hirano, Takashi
AU - Kawate, Norihiko
AU - Kato, Harubumi
PY - 2001
Y1 - 2001
N2 - Telomerase activity in 16 pleural effusions was studied using an in situ telomerase repeat amplification protocol (TRAP) assay on cytospin preparations. Six of nine cytologically malignant specimens contained telomerase-positive cells (67%), and in two further specimens, suspicious positive cells were seen. Two of four atypical specimens contained telomerase-positive cells, whereas two benign cases were telomerase-negative. No mesothelial cells showed telomerase reactivity. Thus, telomerase activity was specific for malignancy and it was always found only in malignant cells. The results suggest that telomerase activity measured with this in situ method can be a valuable complement in the assessment of malignancy in pleural effusions. Diagn. Cytopathol. 2001;24: 11-15.
AB - Telomerase activity in 16 pleural effusions was studied using an in situ telomerase repeat amplification protocol (TRAP) assay on cytospin preparations. Six of nine cytologically malignant specimens contained telomerase-positive cells (67%), and in two further specimens, suspicious positive cells were seen. Two of four atypical specimens contained telomerase-positive cells, whereas two benign cases were telomerase-negative. No mesothelial cells showed telomerase reactivity. Thus, telomerase activity was specific for malignancy and it was always found only in malignant cells. The results suggest that telomerase activity measured with this in situ method can be a valuable complement in the assessment of malignancy in pleural effusions. Diagn. Cytopathol. 2001;24: 11-15.
KW - Cytology
KW - Effusions
KW - Telomerase
KW - TRAP in situ
UR - http://www.scopus.com/inward/record.url?scp=0035160611&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035160611&partnerID=8YFLogxK
U2 - 10.1002/1097-0339(200101)24:1<11::AID-DC1001>3.0.CO;2-A
DO - 10.1002/1097-0339(200101)24:1<11::AID-DC1001>3.0.CO;2-A
M3 - Article
C2 - 11135462
AN - SCOPUS:0035160611
VL - 24
SP - 11
EP - 15
JO - Diagnostic Cytopathology
JF - Diagnostic Cytopathology
SN - 8755-1039
IS - 1
ER -