In vitro selection of novel peptide agonists for human somatostatin receptor subtype-2 using a water-in-oil microdroplet platform

T. Sakurai, R. Iizuka*, Y. Nakamura, J. Ishii, A. Kondo, A. Iguchi, Donghyun Yoon, Tetsushi Sekiguchi, Shuichi Shoji, T. Funatsu

*この研究の対応する著者

研究成果: Conference contribution

抄録

Here we present an in vitro selection method to obtain peptide agonists for G protein-coupled receptors (GPCRs) using a water-in-oil (W/O) microdroplet platform. Using this method, we successfully identified novel peptide agonists for human somatostatin receptor subtype-2 (SSTR2) from a library of partially randomized SST sequences. This result demonstrates that our method will be a powerful platform for identifying novel peptide agonists for human GPCRs with known and unknown endogenous ligands.

本文言語English
ホスト出版物のタイトル20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
出版社Chemical and Biological Microsystems Society
ページ593-594
ページ数2
ISBN(電子版)9780979806490
出版ステータスPublished - 2016
イベント20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
継続期間: 2016 10 92016 10 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
国/地域Ireland
CityDublin
Period16/10/916/10/13

ASJC Scopus subject areas

  • 制御およびシステム工学

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