In vivo O2-transporting ability of totally synthetic artificial red cell (lipid-heme-microsphere) is described. O2-Binding affinity of the lipid-heme-microsphere (P( 1/2 )(O2): ca. 40 Torr at 37°C was slightly lower than that of red cell (human blood) and its O2-association and -dissociation rate constants were larger than those of hemoglobin. O2-Solubility of the lipid-heme-microsphere dispersion was estimated. Highly O2-dissolved aqueous solution can be prepared by the prescription of the lipid-heme-microsphere. The totally synthetic artificial red cell suspension was intravenously injected into hemorrhagic beagles (8 kg). Circulation life-time of each constituent of this system and O2-consumption by the lipid-heme was determined. These results suggest that the lipid-heme-microsphere has an ability to act as an efficient O2-carrier in blood stream.
|ジャーナル||Japanese Journal of Artificial Organs|
|出版ステータス||Published - 1994|
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