In Vivo Redox-Responsive Sol-Gel/Gel-Sol Transition of Star Block Copolymer Solution Based on Ionic Cross-Linking

Yoshiyuki Nakagawa, Seiichi Ohta, Akira Sugahara, Masashi Okubo, Atsuo Yamada, Taichi Ito*

*この研究の対応する著者

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Redox-responsive hydrogels have the potential for application in various fields, including biomedical science. We have developed a redox-responsive star block copolymer hydrogel based on iron ion cross-linking. The addition of the ferric ion (Fe3+) induced gelation of the star block copolymer solution within a few seconds, whereas the addition of the ferrous ion (Fe2+) did not. The resulting hydrogels cross-linked using Fe3+ showed storage moduli (G′) of 26-1400 Pa and were stable under physiological conditions for as long as 1 month. The cross-linking between the star arms produced by the addition of Fe3+ enabled a fast, redox-responsive sol-gel/gel-sol transition. Furthermore, the hydrogel showed excellent injectability and biocompatibility in vivo, resulting in a rapid sol-gel/gel-sol transition in subcutaneous tissues in response to redox stimuli, such as the administration of ascorbic acid or hydrogen peroxide.

本文言語English
ページ(範囲)5539-5548
ページ数10
ジャーナルMacromolecules
50
14
DOI
出版ステータスPublished - 2017 7月 25
外部発表はい

ASJC Scopus subject areas

  • 有機化学
  • ポリマーおよびプラスチック
  • 無機化学
  • 材料化学

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