抄録
The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.
本文言語 | English |
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ページ(範囲) | 97-104 |
ページ数 | 8 |
ジャーナル | International Archives of Occupational and Environmental Health |
巻 | 45 |
号 | 2 |
DOI | |
出版ステータス | Published - 1980 6月 |
外部発表 | はい |
ASJC Scopus subject areas
- 公衆衛生学、環境および労働衛生
- 健康、毒物学および変異誘発