抄録
The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 97-104 |
| ページ数 | 8 |
| ジャーナル | International Archives of Occupational and Environmental Health |
| 巻 | 45 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 1980 6 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
これを引用
In vivo studies on methemoglobin formation by sodium nitrite. / Imaizumi, Kazuhiko; Tyuma, Itiro; Imai, Kiyohiro; Kosaka, Hiroaki; Ueda, Yoshihiro.
：: International Archives of Occupational and Environmental Health, 巻 45, 番号 2, 06.1980, p. 97-104.研究成果: Article
}
TY - JOUR
T1 - In vivo studies on methemoglobin formation by sodium nitrite
AU - Imaizumi, Kazuhiko
AU - Tyuma, Itiro
AU - Imai, Kiyohiro
AU - Kosaka, Hiroaki
AU - Ueda, Yoshihiro
PY - 1980/6
Y1 - 1980/6
N2 - The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.
AB - The oral LD5o of NaNO2 for rats was found to be 0.15 g per kg body weight. The methemoglobin level increased to 45-80%, 1 h after the administration of the LD5o dose and returned to the normal level after 24 h. The dose-maximum methemoglobin concentration curve was found to be Sshaped. Formation of nitrosyl hemoglobin preceded that of methemoglobin, its maximum concentration being a quarter of that of the latter derivative. In rats receiving 0.5% NaNO2 as drinking water, the concentration of methemoglobin showed a characteristic daily change (4 to 88%) due to the circadian rhythm of the animal in drinking. After 6 months, slight nitrosyl hemoglobin production, Heinz body formation, anisocytosis, and hypohemoglobinemia were observed.
KW - Methemoglobin
KW - Nitrite
KW - Nitrosyl hemoglobin
UR - http://www.scopus.com/inward/record.url?scp=0018864739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018864739&partnerID=8YFLogxK
U2 - 10.1007/BF01274129
DO - 10.1007/BF01274129
M3 - Article
C2 - 7364495
AN - SCOPUS:0018864739
VL - 45
SP - 97
EP - 104
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
SN - 0340-0131
IS - 2
ER -