@article{1734f77419214cfabb9d197278888ecd,
title = "In vivometal-catalyzed SeCT therapy by a proapoptotic peptide",
abstract = "Selective cell tagging (SeCT) therapy is a strategy for labeling a targeted cell with certain chemical moietiesviaa catalytic chemical transformation in order to elicit a therapeutic effect. Herein, we report a cancer therapy based on targeted cell surface tagging with proapoptotic peptides (Ac-GGKLFG-X; X = reactive group) that induce apoptosis when attached to the cell surface. Using either Au-catalyzed amidation or Ru-catalyzed alkylation, these proapoptotic peptides showed excellent therapeutic effects bothin vitroandin vivo. In particular, co-treatment with proapoptotic peptide and the carrier-Ru complex significantly and synergistically inhibited tumor growth and prolonged survival rate of tumor-bearing mice after only a single injection. This is the first report of Ru catalyst applicationin vivo, and this approach could be used in SeCT for cancer therapy.",
author = "Peni Ahmadi and Kyohei Muguruma and Chang, {Tsung Che} and Satoru Tamura and Kazuki Tsubokura and Yasuko Egawa and Takehiro Suzuki and Naoshi Dohmae and Yoichi Nakao and Katsunori Tanaka",
note = "Funding Information: All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of RIKEN and approved by the Animal Ethics Committee of RIKEN (W2019-2-049). This work was nancially supported by the AMED Grant JP15KM0908001, a research grant from the Astel-las Foundation, Mizutani Foundation for Glycoscience, and JSPS KAKENHI Grant Numbers, JP19J00396 (to K. M.), JP20K15968 (to K. M.), JP19K15708 (to T. C. C.), JP21H02065 (to K. Tanaka), JP21K19042 (to K. Tanaka). This work was also funded by the subsidy allocated to Kazan Federal University for state assignment in the sphere of scientic activities (0671-2020-0063), with the support of the Kazan Federal University Strategic Academic Leadership Program. Funding Information: All animal procedures were performed in accordance with the Guidelines for Care and Use of Laboratory Animals of RIKEN and approved by the Animal Ethics Committee of RIKEN (W2019-2-049). This work was financially supported by the AMED Grant JP15KM0908001, a research grant from the Astellas Foundation, Mizutani Foundation for Glycoscience, and JSPS KAKENHI Grant Numbers, JP19J00396 (to K. M.), JP20K15968 (to K. M.), JP19K15708 (to T. C. C.), JP21H02065 (to K. Tanaka), JP21K19042 (to K. Tanaka). This work was also funded by the subsidy allocated to Kazan Federal University for state assignment in the sphere of scientific activities (0671-2020-0063), with the support of the Kazan Federal University Strategic Academic Leadership Program. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",
year = "2021",
month = oct,
day = "7",
doi = "10.1039/d1sc01784e",
language = "English",
volume = "12",
pages = "12266--12273",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "37",
}