Increase in the septal vasopressin content by prolyl endopeptidase inhibitors in rats

Naoyoshi Miura*, Shigenobu Shibata, Shigenori Watanabe

*この研究の対応する著者

研究成果: Article査読

40 被引用数 (Scopus)

抄録

Prolyl endopeptidase (PEP; EC 3.4.21.26) cleaves the Pro-Arg bond of arginine-vasopressin (AVP). This study investigated the effects of PEP inhibitors, 1-[1-(benzyloxycarbonyl)-l-prolyl]prolinal (Z-Pro-prolinal) and 1-[3-(2-indanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on the AVP content in the septum of rats. Oral administration of Z-Pro-prolinal (100 mg/kg) and Z-321 (100 mg/kg) significantly increased the septal AVP content. At 10 mg/kg, Z-321 slightly increased the content. In contrast, the d-thioprolyl form of Z-321 (100 mg/kg), which lacks an inhibitory effect on the enzyme, failed to affect the AVP content. These results indicate that PEP inhibitors increase the content of AVP through inhibition of the enzyme activity in vivo. Therefore, it is suggested that PEP may contribute to the degradation of endogenous AVP in the brain.

本文言語English
ページ(範囲)128-130
ページ数3
ジャーナルNeuroscience Letters
196
1-2
DOI
出版ステータスPublished - 1995 8 18
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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