Increased erythrocyte aggregation in diabetes mellitus and its relationship to glycosylated haemoglobin and retinopathy

M. Satoh, K. Imaizumi, T. Bessho, T. Shiga

研究成果: Article査読

44 被引用数 (Scopus)

抄録

The velocity of erythrocyte aggregation in vitro was determined in 15 non-diabetic and 28 Type 1 (insulin-dependent) diabetic subjects, in autologous plasma under uniform shear flow using a rheoscope combined with a television image analyzer and a computer. In the diabetic subjects, the velocity of aggregation showed a significant correlation with the haemoglobin A1 level, and was significantly increased in the proliferative retinopathy group. An alteration of plasma protein composition in the diabetic subjects (increase of Ø- and α2-fractions) also influenced erythrocyte aggregation, being related to the haemoglobin A1 level. The percentage of the Ø-fraction and a parameter, (α2+φ)/albumin, defined by plasma electrophoresis, showed a strong correlation with the velocity of aggregation.

本文言語English
ページ(範囲)517-521
ページ数5
ジャーナルDiabetologia
27
5
DOI
出版ステータスPublished - 1984 11
外部発表はい

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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