Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats

Kei Nagashima, Sadamu Nakai, Masahiro Konishi, Liu Su, Kazuyuki Kanosue

研究成果: Article査読

14 被引用数 (Scopus)

抄録

We examined the effect of hypertonic saline injection on heat-escape/cold-seeking behavior in desalivated rats. Rats were exposed to 40°C heat after normal (154 mM NaCl, control) or hypertonic saline (2,500 mM NaCl) injection (1 ml/100 g body wt). The rats received a 0°C air for 30 s when they entered a specific area in an experimental box. Core temperature (Tc) surpassed 40°C in both conditions when 0°C air was not available. Hypertonic saline injection produced a lower baseline Tc than control [36.9 ± 0.2 and 37.9 ± 0.2°C (means ± SE), P < 0.05] and a greater number of 0±C air rewards during the 2-h heat with lower To at the end (48 ± 1 and 34 ± 2, 37.6 ± 0.1, and 37.3 ± 0.1°C in the control and hypertonic saline injection trial, respectively, P < 0.05, n = 6). However, Tc was similar (37.7 ± 0.2 and 37.6 ± 0.4°C in the control and hypertonic saline injection trial, n = 5) when 0°C air was automatically and intermittently (35 times) given during the heat. Rats augment heat-defense mechanisms in response to osmotic stress by lowering the baseline Tc and increasing heat-escape/cold-seeking behavior.

本文言語English
ページ(範囲)R1031-R1036
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
280
4 49-4
DOI
出版ステータスPublished - 2001
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 生理学(医学)

フィンガープリント

「Increased heat-escape/cold-seeking behavior following hypertonic saline injection in rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル