Increases in gene-targeting frequencies due to disruption of kueA as a ku80 homolog in citric acid-producing aspergillus niger

Yuki Honda, Keiichi Kobayashi, Kohtaro Kirimura

研究成果: Article査読

12 被引用数 (Scopus)

抄録

Low efficiencies of gene targeting hamper functional genomics in industrially important strains of Aspergillus niger. To generate strains showing high gene-targeting frequencies in A. niger WU-2223L producing citric acid, disruption of kueA encoding Ku80 homolog was performed. Disruption of kueA increased gene-targeting frequencies to 70%, and had no effect on citric acid production.

本文言語English
ページ(範囲)1594-1596
ページ数3
ジャーナルBioscience, Biotechnology and Biochemistry
75
8
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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