Incremental short maximal exercise increases urinary liver-type fatty acid-binding protein in adults without CKD

Keisei Kosaki, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Shota Kumamoto, Koichiro Tanahashi, Hiroshi Kumagai, Kenjiro Kimura, Yugo Shibagaki, Seiji Maeda*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Exercise-induced redistribution of tissue blood flow decreases the renal blood flow in an exercise intensity-dependent manner. However, the acute effects of incremental short maximal exercise on renal tubular conditions remain unknown. The purpose of this study was to investigate the acute effects of incremental short maximal exercise on the urinary liver-type fatty acid-binding protein, which is a highly sensitive tubular biomarker that correlates excellently with peritubular capillary blood flow. A total of 116 adults (aged 24-83 years) without chronic kidney disease performed the incremental short maximal exercise using a cycling ergometer, wherein the exercise sequence consisted of commencing with a 2-min workout period at 20 W (as a warm-up period) and then followed by a 10-20 W increase every 1 minute until termination criteria were reached. Urinary samples were gathered before and immediately after the exercise to evaluate the concentrations of urinary creatinine, albumin, and liver-type fatty acid-binding protein. Urinary excretion levels of albumin and liver-type fatty acid-binding protein were significantly increased post-exercise (P <.001 and P =.008, respectively). Furthermore, the % change in urinary liver-type fatty acid-binding protein levels after exercise was found to correlate independently with age, estimated glomerular filtration rate at baseline, and the % change in urinary albumin (Model R2 = 0.451, P <.001). Our findings suggest that incremental short maximal exercise may lead to acute slightly adverse effects on tubular conditions, especially in young adults or adults with lower renal function, even without chronic kidney disease.

本文言語English
ページ(範囲)709-715
ページ数7
ジャーナルScandinavian Journal of Medicine and Science in Sports
30
4
DOI
出版ステータスPublished - 2020 4 1
外部発表はい

ASJC Scopus subject areas

  • 整形外科およびスポーツ医学
  • 理学療法、スポーツ療法とリハビリテーション

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