Induced pluripotent stem cell differentiation under constant shear stress

N. K. Mohd Zin, K. Sakaguchi, Y. Haraguchi, T. Yagi, K. Matsuura, T. Shimizu, M. Umezu

研究成果: Conference contribution

抜粋

Mechanotransduction in in-vitro studies has yet to be done extensively using human induced pluripotent (hiPS) cells. These external mechanical factors are important controlling factor for cell differentiation at a cellular level particularly in cardiomyocytes cells. Cells in a living body are being exposed to many kind of stresses; shear stress in particular modulates cellular function in a living body. Similarly, we are trying to understand the link between the shear stress in the bioreactor and the differentiation effects it has on iPS cells. In this study, we investigate the difference of strictly uniform laminar shear stress with a non-uniform laminar flow and its effects on the cell survival rate and differentiation. Additionally, the elimination of biochemical factors were done to satisfy the need of demand for clinically usable cells for the near future use. By eliminating cytokine induced differentiation. In addition, information pertaining to relationship between fluid shear stress, cellular deformations, cell differentiation and cell survival rate could provide a more optimised condition for cultivation specific type of cells within a shorter time period.

元の言語English
ホスト出版物のタイトル7th WACBE World Congress on Bioengineering, 2015
編集者Chwee Teck Lim, James Goh
出版者Springer Verlag
ページ7-10
ページ数4
ISBN(印刷物)9783319194516
DOI
出版物ステータスPublished - 2015
イベント7th World Congress on Bioengineering, WACBE 2015 - Kent Ridge, Singapore
継続期間: 2015 7 62015 7 8

出版物シリーズ

名前IFMBE Proceedings
52
ISSN(印刷物)1680-0737

Other

Other7th World Congress on Bioengineering, WACBE 2015
Singapore
Kent Ridge
期間15/7/615/7/8

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • これを引用

    Mohd Zin, N. K., Sakaguchi, K., Haraguchi, Y., Yagi, T., Matsuura, K., Shimizu, T., & Umezu, M. (2015). Induced pluripotent stem cell differentiation under constant shear stress. : C. T. Lim, & J. Goh (版), 7th WACBE World Congress on Bioengineering, 2015 (pp. 7-10). (IFMBE Proceedings; 巻数 52). Springer Verlag. https://doi.org/10.1007/978-3-319-19452-3_3