@inproceedings{cfe8a4abec424c06a0a2f5789d1194b5,

title = "Induced pluripotent stem cell differentiation under constant shear stress",

abstract = "Mechanotransduction in in-vitro studies has yet to be done extensively using human induced pluripotent (hiPS) cells. These external mechanical factors are important controlling factor for cell differentiation at a cellular level particularly in cardiomyocytes cells. Cells in a living body are being exposed to many kind of stresses; shear stress in particular modulates cellular function in a living body. Similarly, we are trying to understand the link between the shear stress in the bioreactor and the differentiation effects it has on iPS cells. In this study, we investigate the difference of strictly uniform laminar shear stress with a non-uniform laminar flow and its effects on the cell survival rate and differentiation. Additionally, the elimination of biochemical factors were done to satisfy the need of demand for clinically usable cells for the near future use. By eliminating cytokine induced differentiation. In addition, information pertaining to relationship between fluid shear stress, cellular deformations, cell differentiation and cell survival rate could provide a more optimised condition for cultivation specific type of cells within a shorter time period.",

keywords = "Cell viability, IPSC, Shear stress",

author = "{Mohd Zin}, {N. K.} and K. Sakaguchi and Y. Haraguchi and T. Yagi and K. Matsuura and T. Shimizu and M. Umezu",

year = "2015",

doi = "10.1007/978-3-319-19452-3_3",

language = "English",

isbn = "9783319194516",

series = "IFMBE Proceedings",

publisher = "Springer Verlag",

pages = "7--10",

editor = "Lim, {Chwee Teck} and James Goh",

booktitle = "7th WACBE World Congress on Bioengineering, 2015",

note = "7th World Congress on Bioengineering, WACBE 2015 ; Conference date: 06-07-2015 Through 08-07-2015",

}