Induction of anovulatory sterility by neonatal treatment with 5β-dihydrotestosterone in female rats

Y. Arai, K. Yamanouchi, S. Mizukami, R. Yanai, K. Shibata, H. Nagasawa

    研究成果: Article査読

    21 被引用数 (Scopus)

    抄録

    Wistar female rats were injected with testosterone (T) or 5β-dihydrotestosterone (5β-DHT) for the first 5 days of life. Neonatal treatment with 1 mg of T resulted in anovulatory persistent oestrous syndrome in 100% of the animals. In the females injected with 1 mg of 5β-DHT, 74% of the treated rats became sterile at 120 days of age. In addition, 0.5 mg 5β-DHT was also effective in inducing anovulatory persistent oestrus; the incidence of sterility was 10 and 80% at 60 and 120 days of age, respectively. When daily dose of 5β-DHT was reduced to 0.1 mg, however, only 33% of the rats resulted in sterility. These results suggest that the free form of T and non-aromatizable androgen, 5β-DHt, can permanently suppress the development of female type of neuroendocrine regulation. The possible participation of the process other than the central aromatization in androgenization will be discussed.

    本文言語English
    ページ(範囲)439-443
    ページ数5
    ジャーナルActa Endocrinologica
    96
    4
    出版ステータスPublished - 1981

    ASJC Scopus subject areas

    • Endocrinology

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