Induction of Photoresponse by the Hydrolysis of Polyphosphoinositides in the Hermissenda Type B Photoreceptor

M. Sakakibara, D. L. Alkon, T. Kouchi, H. Inoue, T. Yoshioka

研究成果: Article査読

27 被引用数 (Scopus)

抄録

Direct evidence that the photoresponse of the Hermissenda type B photoreceptor cell is triggered directly by the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) was obtained. Neomycin and spermine, which inhibit PIP2 breakdown, suppressed light response, while injection of inositol 1,4,5-trisphosphate (IP3), guanosine 5′-(3-O-thio)triphosphate (GTPγS), guanosine 5′-(2-O-thio)diphosphate (GDPβS), cAMP, cGMP did not alter the light-induced Na+ influx underlying the photoresponse. Suppression of the photoresponse was also observed with decrease of total amount of membraneous PIP2 induced by injection of the phosphoinositides (PI) turnover inhibitors, isobutylmethylxanthine (IBMX), LiCl and R 59022.

本文言語English
ページ(範囲)299-306
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
202
1
DOI
出版ステータスPublished - 1994 7 15
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 生物理学
  • 生化学

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