Inferring behavioral-level circuits of Caenorhabditis elegans from the topology of its wiring diagram

Yunkyu Sohn*, Jaeseung Jeong

*この研究の対応する著者

研究成果: Conference contribution

抄録

The existence of anatomical basis of functional modularity in the brain has been postulated. Previous studies in the field of theoretical neuroanatomy claimed the segregated nature of cortical areas with their physiological functions by analyzing fiber connection data of mammalian brains. The aim of this study was to investigate, using modularity-based spectral community (cluster) detection algorithm, whether the behavioral-level circuits of Caenorhabditis elegans (C. elegans), which is the only animal that we have a complete wiring diagram of its global nervous system, can be inferred from the topology of its wiring diagram (neuro-synaptic level network) or not. We found that neurons belonging to strong clusters exhibit a hierarchical relationship with the worm's behavioral-level circuits. In addition, we demonstrate the possible existence of strong body-spanning clusters in real neuronal networks.

本文言語English
ホスト出版物のタイトルProceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
ページ748-752
ページ数5
DOI
出版ステータスPublished - 2007 12月 1
外部発表はい
イベント7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE - Boston, MA, United States
継続期間: 2007 1月 142007 1月 17

出版物シリーズ

名前Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE

Conference

Conference7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE
国/地域United States
CityBoston, MA
Period07/1/1407/1/17

ASJC Scopus subject areas

  • バイオテクノロジー
  • 遺伝学
  • バイオエンジニアリング

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