Influence of hydrostatic pressure gradients on regulation of plasma volume after exercise

Gary W. Mack, Roger Yang, Alan R. Hargens, Kei Nagashima, Andrew Haskell

研究成果: Article

29 引用 (Scopus)

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The impact of posture on the immediate recovery of intravascular fluid and protein after intense exercise was determined in 14 volunteers. Forces which govern fluid and protein movement in muscle interstitial fluid pressure (P(ISF)), interstitial colloid osmotic pressure (COP(i)), and plasma colloid osmotic pressure (COP(p)) were measured before and after exercise in the supine or upright position. During exercise, plasma volume (PV) decreased by 5.7 ± 0.7 and 7.0 ± 0.5 ml/kg body weight in the supine and upright posture, respectively. During recovery, PV returned to its baseline value within 30 min regardless of posture. PV fell below this level by 60 and 120 min in the supine and upright posture, respectively (P < 0.05). Maintenance of PV in the upright position was associated with a decrease in systolic blood pressure, and increase in COP(p) (from 25 ± 1 to 27 ± 1 mmHg; P < 0.05), and an increase in P(ISF) (from 5 ± 1 to 6 ± 2 mmHg), whereas COP(i) was unchanged. Increased P(ISF) indicates that the hydrostatic pressure gradient favors fluid movement into the vascular space. However, retention of the recaptured fluid in the plasma is promoted only in the upright posture because of increased COP(p).

元の言語English
ページ(範囲)667-675
ページ数9
ジャーナルJournal of Applied Physiology
85
発行部数2
DOI
出版物ステータスPublished - 1998 8
外部発表Yes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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