Influence of short-term hyperenergetic, high-fat feeding on appetite, appetite-related hormones, and food reward in healthy men

Alice E. Thackray, Scott A. Willis, David J. Clayton, David R. Broom, Graham Finlayson, Fernanda R. Goltz, Jack A. Sargeant, Rachel M. Woods, David J. Stensel, James A. King*

*この研究の対応する著者

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Short-term overfeeding may provoke compensatory appetite responses to correct the energy surplus. However, the initial time-course of appetite, appetite-related hormone, and reward-related responses to hyperenergetic, high-fat diets (HE-HFD) are poorly characterised. Twelve young healthy men consumed a HE-HFD (+50% energy, 65% fat) or control diet (36% fat) for seven days in a randomised crossover design. Mean appetite perceptions were determined during an oral glucose tolerance test (OGTT) before and after each diet. Fasted appetite perceptions, appetite-related hormones, and reward parameters were measured pre-diet and after 1-, 3-and 7-days of each diet. The HE-HFD induced a pre-to-post diet suppression in mean appetite during the OGTT (all ratings p ≤ 0.058, effect size (d) ≥ 0.31), and reduced the preference for high-fat vs. low-fat foods (main effect diet p = 0.036, d = 0.32). Fasted leptin was higher in the HE-HFD than control diet (main effect diet p < 0.001, d = 0.30), whilst a diet-by-time interaction (p = 0.036) revealed fasted acylated ghrelin was reduced after 1-, 3-and 7-days of the HE-HFD (all p ≤ 0.040, d ≥ 0.50 vs. pre-diet). Appetite perceptions and total peptide YY in the fasted state exhibited similar temporal patterns between the diets (diet-by-time interaction p ≥ 0.077). Seven days of high-fat overfeeding provokes modest compensatory changes in subjective, hormonal, and reward-related appetite parameters.

本文言語English
論文番号2635
ページ(範囲)1-15
ページ数15
ジャーナルNutrients
12
9
DOI
出版ステータスPublished - 2020 9月
外部発表はい

ASJC Scopus subject areas

  • 食品科学
  • 栄養および糖尿病

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