Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children

Takaharu Negoro, Kanami Orihara, Tomoko Irahara, Hiroshi Nishiyama, Kanae Hagiwara, Risa Nishida, Hiroki Takagi, Kazue Satoh, Yoshiki Yamamoto, Shunichi Shimizu, Tamio Hagiwara, Masakazu Ishii, Toshihiro Tanioka, Yasuko Nakano, Ken Takeda, Isao Yoshimura, Yoji Iikura, Takashi Tobe

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Although many single nucleotide polymorphism (SNP) studies have reported an association of atopy, allergic diseases and total serum immunoglobulin E (IgE) levels, almost all of these studies sought risk factors for the onset of these allergic diseases. Furthermore, many studies have analyzed a single gene and hardly any have analyzed environmental factors. In these analyses, the results could be masked and the effects of other genes and environmental factors may be decreased. Here, we described the correlation between four genes [interleukin (IL)-4 (C-590T), IL-4 receptor (A1652G), FCER1B (G6842A) and STAT6 (G2964A)] in connection with IgE production; the role of IL-10 (C-627A) as a regulatory cytokine of allergy; and the severity of food allergy (FA) and atopic eczema (AE) in 220 Japanese allergic children. In addition to these SNPs, environmental factors, i.e., patient's attitude, indoor envirmonment, and so on, were also investigated in this study. Our study was retrospective, and the correlation was analyzed by our defined clinical scores divided into three terms: worst symptoms, recent symptoms and general amelioration at the most recent examination during the disease course. Our results indicated that IL-10 AA, the genotype with lower IL-10 production, is associated with higher IgE levels in the serum (p < 0.0001, estimate; 0.912). Marginal liver abnormalities were observed in the subject group with both FA and AE (p < 0.1191, estimate; 0.1490). Our defined clinical scores enabled evaluation of various aspects of disease severity. Based on the scores, while no single SNP selected in this study determined severity, the combination of the SNP with laboratory data and environmental factors appeared to determine severity.

本文言語English
ページ(範囲)583-590
ページ数8
ジャーナルPediatric Allergy and Immunology
17
8
DOI
出版ステータスPublished - 2006 12
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

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