Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice

Hidekazu Fujimaki, Yoshika Kurokawa, Masaki Kakeyama, Naoki Kunugita, Yukiko Fueta, Takaichi Fukuda, Hajime Hori, Keiichi Arashidani

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Objective: The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied. Methods: Evaluation of NGF in the hippocampus was performed by ELISA and RT-PCR. Results: Exposure to 80 and 400 ppb FA significantly increased the brain NGF levels in the immunized mice. Evaluation of the NGF levels in the hippocampus of immunized mice showed that 400 ppb FA significantly increased the NGF content. The RT-PCR evaluation also showed higher concentrations of hippocampal NGF mRNA in the mice exposed to 80 and 400 ppb FA with immunization. Conclusion: Exposure of immunized mice to low levels of FA significantly increases NGF levels in the hippocampus.

本文言語English
ページ(範囲)373-375
ページ数3
ジャーナルNeuroImmunoModulation
11
6
DOI
出版ステータスPublished - 2004 10 27
外部発表はい

ASJC Scopus subject areas

  • 免疫学
  • 内分泌学
  • 神経学
  • 内分泌系および自律システム

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