Inhibition effect of aggregation of phospholipid vesicles by incorporation of glycolipids

Shinji Takeoka, Hiromi Sakai, Hiroyuki Ohno, Kiyoshi Yoshimura, Eishun Tsuchida

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Oligosaccharide fatty acid esters (glycolipids) [GkmCn; k, number of α-1,4-bound glucose unit (G) (k = 2, 5, 7); m, number of fatty acid (C) (m = 1, 2); and n, number of methylene unit (n = 12, 16, 22)] were synthesized. Aggregation of unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) below a gel-to-liquid crystalline phase transition temperature (43°C) were inhibited by incorporation of glycolipids into bilayer membrane and G51C16 was clarified to be the most effective structure. The complete inhibition by G51C16 could be achieved by the addition of 2 mol% of G51C16 to less than 0.5 wt% of DPPC liposomes at room temperature. This glycolipid also restricts the aggregation of liposomes induced by polyethyleneglycol or polysaccharide and improves the packing of lipids in the bilayer membrane.

本文言語English
ページ(範囲)351-358
ページ数8
ジャーナルJournal of Colloid And Interface Science
152
2
DOI
出版ステータスPublished - 1992 9

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 生体材料
  • 表面、皮膜および薄膜
  • コロイド化学および表面化学

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