Inhibition effect of aggregation of phospholipid vesicles by incorporation of glycolipids

Shinji Takeoka, Hiromi Sakai, Hiroyuki Ohno, Kiyoshi Yoshimura, Eishun Tsuchida

研究成果: Article

8 引用 (Scopus)

抜粋

Oligosaccharide fatty acid esters (glycolipids) [GkmCn; k, number of α-1,4-bound glucose unit (G) (k = 2, 5, 7); m, number of fatty acid (C) (m = 1, 2); and n, number of methylene unit (n = 12, 16, 22)] were synthesized. Aggregation of unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) below a gel-to-liquid crystalline phase transition temperature (43°C) were inhibited by incorporation of glycolipids into bilayer membrane and G51C16 was clarified to be the most effective structure. The complete inhibition by G51C16 could be achieved by the addition of 2 mol% of G51C16 to less than 0.5 wt% of DPPC liposomes at room temperature. This glycolipid also restricts the aggregation of liposomes induced by polyethyleneglycol or polysaccharide and improves the packing of lipids in the bilayer membrane.

元の言語English
ページ(範囲)351-358
ページ数8
ジャーナルJournal of Colloid And Interface Science
152
発行部数2
DOI
出版物ステータスPublished - 1992 9

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

フィンガープリント Inhibition effect of aggregation of phospholipid vesicles by incorporation of glycolipids' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用