Inhibition of pituitary prolactin secretion by human placental lactogen in rats

H. Nagasawa, R. Yanai, K. Yamanouchi

    研究成果: Article

    11 引用 (Scopus)

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    Intact female rats given twice daily injections of 1 mg human placental lactogen (HPL) showed continued dioestrous vaginal smears and their ovarian corpora lutea were found to be hypertrophied and functional. The serum prolactin level was significantly lower in these rats than in the controls at dioestrus as well as at pro oestrus. Twice daily injections of 0.5 or 2 mg HPL to ovariectomized rats decreased serum and pituitary levels of prolactin and increased hypothalamic activity of prolactin inhibiting hormone, although the effect was less at the lower dose. Human placental lactogen had no direct effect on pituitary prolactin in vitro. These findings have demonstrated that HPL, like prolactin itself, inhibits prolactin secretion by acting indirectly on the pituitary through the hypothalamus.

    元の言語English
    ページ(範囲)115-120
    ページ数6
    ジャーナルJournal of Endocrinology
    71
    発行部数1
    出版物ステータスPublished - 1976

    ASJC Scopus subject areas

    • Endocrinology

    フィンガープリント Inhibition of pituitary prolactin secretion by human placental lactogen in rats' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Nagasawa, H., Yanai, R., & Yamanouchi, K. (1976). Inhibition of pituitary prolactin secretion by human placental lactogen in rats. Journal of Endocrinology, 71(1), 115-120.