Inhibition of thyroxine-induced resorption of tadpole tail by adenosine 3',5'-cyclic monophosphate

K. Yamamoto, S. Kikuyama, I. Yasumasu

    研究成果: Article

    10 引用 (Scopus)

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    Small segments of tail of Bufo bufo japonicus tadpoles were cultured in medium containing thyroxine (T4) and dibutyryl cyclic AMP (dbcAMP). Like prolactin, the cyclic nycleotide blocked T4-induced shrinkage of tail pieces. Histological study of the segments after 4 days of culture revealed that dbcAMP suppressed degenerative changes induced by T4. The inhibitory effect of prolactin on T4-induced tail regression was promoted by caffeine an inhibitor of adenosine 3',5'-cyclic monophosphate (cyclic AMP)-phosphodiesterase. The effect of prolactin on the level of cyclic AMP in the tail was also studied in vivo. Sixty min after prolactin injection, the cyclic AMP level was 2-3 times the control value. Possible involvement of cyclic AMP in the action of prolactin, which blocks tail resorption induced by T4, was discussed.

    元の言語English
    ページ(範囲)255-261
    ページ数7
    ジャーナルDevelopment Growth and Differentiation
    21
    発行部数3
    出版物ステータスPublished - 1979

      フィンガープリント

    ASJC Scopus subject areas

    • Cell Biology
    • Developmental Biology
    • Anatomy

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