Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms

Shin Ichi Yokota, Takahiro Moriya, Shigenobu Shibata*

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment interferes with photic entrainment signals, there is no information about whether photic entrainment interferes with non-photic entraining signals. We examined whether triazolam (TRZ), a non-photic form of entrainment, could be attenuated by pre-treatment with (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole hydrochloride (MKC-242), a photic enhancing drug. We found that TRZ-induced phase advances in hamster behavioral circadian rhythms and the increase of locomotor activity were both significantly attenuated by MKC-242. Thus, in hamsters, the photic enhancing drug MKC-242 seemed to hinder benzodiazepine-induced non-photic entrainment.

本文言語English
ページ(範囲)103-106
ページ数4
ジャーナルJournal of Pharmacological Sciences
98
1
DOI
出版ステータスPublished - 2005 5月

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

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