抄録
Flavonoids, (-)-epigallocatechin (1), myricetin (2) and quercetin (3), were investigated for inhibitory effects on E. coli DNA polymerase I and T7 bacteriophage RNA polymerase. In both DNA and RNA synthesis, 1 and 3 inhibited enzyme reactions by non-competitive and mixed type inhibition respecitively, with regard to template DNAs. Myricetin (2) inhibited DNA and RNA polymerase reactions by mixed type and competitive type inhibition, respectively, with template DNAs. It was suggested that 2 interacts with covalently closed/circular DNA.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 882-885 |
| ページ数 | 4 |
| ジャーナル | Experientia |
| 巻 | 44 |
| 号 | 10 |
| DOI | |
| 出版ステータス | Published - 1988 10月 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 生化学、遺伝学、分子生物学（全般）