Inhibitory effect of flavonoids on DNA-dependent DNA and RNA polymerases

K. Shinozuka, Yo Kikuchi, C. Nishino*, A. Mori, S. Tawata

*この研究の対応する著者

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Flavonoids, (-)-epigallocatechin (1), myricetin (2) and quercetin (3), were investigated for inhibitory effects on E. coli DNA polymerase I and T7 bacteriophage RNA polymerase. In both DNA and RNA synthesis, 1 and 3 inhibited enzyme reactions by non-competitive and mixed type inhibition respecitively, with regard to template DNAs. Myricetin (2) inhibited DNA and RNA polymerase reactions by mixed type and competitive type inhibition, respectively, with template DNAs. It was suggested that 2 interacts with covalently closed/circular DNA.

本文言語English
ページ(範囲)882-885
ページ数4
ジャーナルExperientia
44
10
DOI
出版ステータスPublished - 1988 10月
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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