Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung

M. Iigo*, T. Nakagawa, C. Ishikawa, Y. Iwahori, M. Asamoto, Kazunaga Yazawa, E. Araki, H. Tsuda

*この研究の対応する著者

研究成果: Article査読

83 被引用数 (Scopus)

抄録

Unsaturated fatty acids, including n-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (C(22:6), DHA) and eicosapentaenoic acid (C(20:5), EPA), and a series of n-6 PUFAs were investigated for their anti-tumour and antimetastatic effects in a subcutaneous (s.c.) implanted highly metastatic colon carcinoma 26 (Co 26Lu) model. EPA and DHA exerted significant inhibitory effects on tumour growth at the implantation site and significantly decreased the numbers of lung metastatic nodules. Oleic acid also significantly inhibited lung metastatic nodules. Treatment with arachidonic acid showed a tendency for reduction in colonization. However, treatment with high doses of fatty acids, especially linoleic acid, increased the numbers of lung metastatic nodules. DHA and EPA only inhibited lung colonizations when administered together with the tumour cells, suggesting that their incorporation is necessary for an influence to be exerted. Chromatography confirmed that contents of fatty acids in both tumour tissues and plasma were indeed affected by the treatments. Tumour cells pretreated with fatty acids in vivo, in particular DHA, also showed a low potential for lung colony formation when transferred to new hosts. Thus, DHA treatment exerted marked antimetastatic activity associated with pronounced change in the fatty acid component of tumour cells. The results indicate that uptake of DHA into tumour cells results in altered tumour cell membrane characteristics and a decreased ability to metastasize.

本文言語English
ページ(範囲)650-655
ページ数6
ジャーナルBritish Journal of Cancer
75
5
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 癌研究
  • 腫瘍学

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