This paper proposes an inter-symbol interference (ISI) suppression scheme employing periodic signals for network MIMO-OFDM systems. Network MIMO-OFDM suffers from the ISI due to long time difference of arrival (TDOA) especially in large cells. In the proposed scheme, the periodic signals generated by only the even-numbered sub-carriers are adopted for ISI-affected users while the traditional non-periodic signals are used for ISI-free users. Moreover, to realize the transmission mode selection between the periodic and non-periodic signals, the theoretical derivation method of the BER is newly derived considering the impact of channel coding. The effectiveness of the proposed method is demonstrated in comparison with the traditional non-periodic transmission by means of computer simulations.