Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda; Naoki Horikoshi; Takayuki Murata; Daisuke Kawashima; Atsuko Sugimoto; Yohei Narita; Hitoshi Kurumizaka; Tatsuya Tsurumi

doi:10.1074/jbc.M113.491167

Interaction between basic residues of epstein-barr virus EBNA1 protein and cellular chromatin mediates viral plasmid maintenance

Teru Kanda^*, Naoki Horikoshi, Takayuki Murata, Daisuke Kawashima, Atsuko Sugimoto, Yohei Narita, Hitoshi Kurumizaka, Tatsuya Tsurumi

^*この研究の対応する著者

理工学術院総合研究所

研究成果: Article › 査読

16 被引用数 (Scopus)

抄録

Background: Epstein-Barr virus episomes piggyback onto cellular chromosomes in latently infected cells. Results: EBNA1 was functionally sound even when arginines within its chromosome binding domains were replaced with lysines. Conclusion: The basic nature of the domains is critically important for the chromosome binding. Significance: Learning how EBNA1 attaches to chromosomes is crucial for understanding the mechanism of stable maintenance of viral episomes.

本文言語	English
ページ（範囲）	24189-24199
ページ数	11
ジャーナル	Journal of Biological Chemistry
巻	288
号	33
DOI	https://doi.org/10.1074/jbc.M113.491167
出版ステータス	Published - 2013 8月 16

ASJC Scopus subject areas

生化学
細胞生物学
分子生物学

文献へのアクセス

10.1074/jbc.M113.491167

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引用スタイル

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AU - Horikoshi, Naoki

AU - Murata, Takayuki

AU - Kawashima, Daisuke

AU - Sugimoto, Atsuko

AU - Narita, Yohei

AU - Kurumizaka, Hitoshi

AU - Tsurumi, Tatsuya

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