Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles

Nao Nishida-Aoki, Takahiro Ochiya*

*この研究の対応する著者

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Abstract MicroRNAs (miRNAs) exhibit many functions in biological activities. Recent studies have shown that miRNAs exist outside cells and are transferred between cells. Extracellular miRNAs are protected from ribonucleases found in body fluids through binding to specific proteins or by being encapsulated in lipid bilayer vesicles. Here, we review the mechanisms of the secretion and uptake as well as the functions of extracellular miRNAs, particularly those encapsulated in extracellular vesicles. Extracellular vesicles are related to cancer progression, and some miRNAs in extracellular vesicles are associated with cancer cells. We describe the transfer of cancer-related miRNAs between cancer cells and non-cancerous cells. Finally, we discuss the anticipated applications of miRNAs present in extracellular vesicles in diagnostics and therapeutics.

本文言語English
論文番号1811
ページ(範囲)1849-1861
ページ数13
ジャーナルCellular and Molecular Life Sciences
72
10
DOI
出版ステータスPublished - 2015 5月 1
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 薬理学
  • 細胞および分子神経科学
  • 細胞生物学

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