Interferon-γ constrains cytokine production of group 2 innate lymphoid cells

Fujimi Kudo, Masashi Ikutani, Yoichi Seki, Takeshi Otsubo, Yuki I. Kawamura, Taeko Dohi, Kenshiro Oshima, Masahira Hattori, Susumu Nakae, Kiyoshi Takatsu, Satoshi Takaki

    研究成果: Article

    18 引用 (Scopus)

    抜粋

    Group 2 innate lymphoid cells (ILC2s) produce a significant amount of interleukin-5 (IL-5), which supports eosinophil responses in various tissues; they also produce IL-13, which induces mucus production and contributes to tissue repair or fibrosis. The ILC2s are activated by alarmins, such as IL-33 released from epithelia, macrophages and natural killer T (NKT) cells in response to infection and allergen exposure, leading to epithelial injury. We examined gene expression in lung ILC2s and found that ILC2s expressed Ifngr1, the receptor for interferon-γ (IFN-γ). Interferon-γ severely inhibited IL-5 and IL-13 production by lung and kidney ILC2s. To evaluate the effects in vivo, we used α-galactosylceramide (α-GalCer) to induce NKT cells to produce IL-33 and IFN-γ. Intraperitoneal injection of α-GalCer in mice induced NKT cell activation resulting in IL-5 and IL-13 production by ILC2s. Administration of anti-IFN-γ together with α-GalCer significantly enhanced the production of IL-5 and IL-13 by ILC2s in lung and kidney. Conversely, cytokine production from ILC2s was markedly suppressed after injection of exogenous IL-33 in Il33-/- mice pre-treated with α-GalCer. Hence, IFN-γ induced or already present in tissues can impact downstream pleiotropic functions mediated by ILC2s, such as inflammation and tissue repair.

    元の言語English
    ページ(範囲)21-29
    ページ数9
    ジャーナルImmunology
    147
    発行部数1
    DOI
    出版物ステータスPublished - 2016 1 1

    ASJC Scopus subject areas

    • Immunology
    • Immunology and Allergy

    フィンガープリント Interferon-γ constrains cytokine production of group 2 innate lymphoid cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kudo, F., Ikutani, M., Seki, Y., Otsubo, T., Kawamura, Y. I., Dohi, T., Oshima, K., Hattori, M., Nakae, S., Takatsu, K., & Takaki, S. (2016). Interferon-γ constrains cytokine production of group 2 innate lymphoid cells. Immunology, 147(1), 21-29. https://doi.org/10.1111/imm.12537