Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats

Megumi Akiyoshi*, Yasutake Shimizu, Masayuki Saito

*この研究の対応する著者

研究成果: Article査読

57 被引用数 (Scopus)

抄録

To clarify effects of interleukin-1 on sympathetic nerve activity, norepinephrine turnover in various organs was assessed in rats after intraperitoneal injection of recombinant human interleukin-1β. Interleukin-1 administration increased norepinephrine turnover in the spleen, lung and hypothalamus without appreciable effect in the heart, liver, submandibular gland, thymus, pancreas, brown adipose tissue and medulla oblongata. Similar changes in norepinephrine turnover were also found after the administration of bacterial endotoxin. It was concluded that interleukin-1 activates the sympathetic nerves specifically in the spleen and lung.

本文言語English
ページ(範囲)1266-1270
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
173
3
DOI
出版ステータスPublished - 1990 12月 31
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生物理学
  • 分子生物学

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