Intra-aneurysmal hemodynamics in a large middle cerebral artery aneurysm with wall atherosclerosis

Satoshi Tateshima, Kazuo Tanishita, Hiroyoshi Omura, James Sayre, J. Pablo Villablanca, Neil Martin, Fernando Vinuela

研究成果: Article

11 引用 (Scopus)

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Background: The remodeling of arterial extra-cellular matrix induced by hemodynamic stimuli is involved in the process of atherosclerosis in the carotid and cerebral arteries. Scarce information is available on the relationship between atherosclerotic changes in brain aneurysms itself and its intra-aneurysmal hemodynamics. Methods: Surgical exploration of a large MCA aneurysm depicted extensive atherosclerotic changes in the aneurysm wall. Computational tomographic angiography of this aneurysm was used to create an in vitro aneurysm model. This model was used to perform intra-aneurysmal flow measurement using particle imaging velocimetry and LDV. Intra-aneurysmal hemodynamic pattern with wall shear stress distribution was compared between areas with and without atherosclerotic changes. Results: No high oscillation of wall shear stress was observed on the atherosclerotic plaque area. However, the magnitude of wall shear stress tended to be higher in the area without atherosclerotic changes than the area with those changes (P < .001). There was no atherosclerotic change at the aneurysm inflow zone, where relatively fast flow velocity and higher magnitude of wall shear stress was noted. Conclusions: This single case of atherosclerosis in an aneurysm shows some similarity in hemodynamic values observed in cases of carotid atherosclerotic plaques.

元の言語English
ページ(範囲)454-462
ページ数9
ジャーナルSurgical Neurology
70
発行部数5
DOI
出版物ステータスPublished - 2008 11
外部発表Yes

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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  • これを引用

    Tateshima, S., Tanishita, K., Omura, H., Sayre, J., Villablanca, J. P., Martin, N., & Vinuela, F. (2008). Intra-aneurysmal hemodynamics in a large middle cerebral artery aneurysm with wall atherosclerosis. Surgical Neurology, 70(5), 454-462. https://doi.org/10.1016/j.surneu.2008.03.035