Intracellular β2-adrenergic receptor signaling specificity in mouse skeletal muscle in response to single-dose β2-agonist clenbuterol treatment and acute exercise

Shogo Sato, Ken Shirato, Ryosuke Mitsuhashi, Daisuke Inoue, Takako Kizaki, Hideki Ohno, Kaoru Tachiyashiki, Kazuhiko Imaizumi*

*この研究の対応する著者

    研究成果: Article査読

    6 被引用数 (Scopus)

    抄録

    The aim of this study was to clarify the intracellular β2- adrenergic receptor signaling specificity in mouse slow-twitch soleus and fast-twitch tibialis anterior (TA) muscles, resulting from single-dose β2-agonist clenbuterol treatment and acute exercise. At 1, 4, and 24 h after single-dose treatment with clenbuterol or after acute running exercise, the soleus and TA muscles were isolated and subjected to analysis. The phosphorylation of p38 mitogen-activated protein kinase (MAPK) increased after single-dose clenbuterol treatment and acute exercise in the soleus muscle but not in the TA muscle. Although there was no change in the phosphorylation of Akt after acute exercise in either muscle, phosphorylation of Akt in the soleus muscle increased after single-dose clenbuterol treatment, whereas that in the TA muscle remained unchanged. These results suggest that p38 MAPK and Akt pathways play a functional role in the adaptation to clenbuterol treatment and exercise, particularly in slow-twitch muscles.

    本文言語English
    ページ(範囲)211-218
    ページ数8
    ジャーナルJournal of Physiological Sciences
    63
    3
    DOI
    出版ステータスPublished - 2013 5月

    ASJC Scopus subject areas

    • 生理学

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