Investigation of primary nucleation phenomena of acetylsalicylic acid crystals induced by ultrasonic irradiation-ultrasonic energy needed to activate primary nucleation

Etsuko Miyasaka, Satomi Ebihara, Izumi Hirasawa

    研究成果: Article

    43 引用 (Scopus)

    抄録

    The purpose of our study is to clarify ultrasonic primary nucleation phenomena for controlling final product size by adjusting the number of primary nuclei. In our previous study, the effect of ultrasonic irradiation on the number of nuclei was investigated under the same supersaturated condition, as a result two novel phenomena were observed. First, there is a region where ultrasonic irradiation inhibits primary nucleation. Second, a specific amount of energy is needed to activate primary nucleation. From this result, it was expected that the ultrasonic energy needed to activate primary nucleation has a certain relationship to the energy necessary to form a stable nucleus. Therefore, we investigated the following: whether ultrasonic irradiation inhibits and activates primary nucleation at various degrees of supersaturation, whether final crystal size relates to the number of nuclei, and whether the ultrasonic energy needed to activate primary nucleation relates to the energy necessary to form a stable nucleus. First, we found that ultrasonic irradiation inhibits and activates primary nucleation at various supersaturated degrees. Second, we found that final crystal size increases or decreases depending on the number of nuclei. Therefore, it was indicated that ultrasonic energy could yield the desired crystal size by inducing suitable nucleation. Third, we found that the ultrasonic energy needed to activate primary nucleation decreases with a decrease in the energy necessary to form a stable nucleus. From this, we can propose criteria for determining the effect of ultrasonic irradiation on primary nucleation by showing diagrams correlating ΔGcrit with Ecrit.

    元の言語English
    ページ(範囲)97-101
    ページ数5
    ジャーナルJournal of Crystal Growth
    295
    発行部数1
    DOI
    出版物ステータスPublished - 2006 9 15

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    acetylsalicylic acid
    Aspirin
    Nucleation
    ultrasonics
    Ultrasonics
    Irradiation
    nucleation
    Crystals
    irradiation
    Acids
    crystals
    nuclei
    energy
    Supersaturation
    supersaturation
    adjusting
    diagrams

    ASJC Scopus subject areas

    • Condensed Matter Physics

    これを引用

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