Investigation of the Dimethylsulfoxide-Trifluoroacetic Acid Oxidation System for the Synthesis of Cystine-Containing Peptides

Takaki Koide, Akira Otaka, Nobutaka Fujii

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Disulfide bonds of peptides were effectively established between S-protected cysteine residues as well as free cysteine residues by the action of dimethylsulfoxide in trifluoroacetic acid. Oxytocin and a-human calcitonin gene-related peptide were synthesized using this oxidation system. The feasibility of this method for the formation of two disulfide bridges of apamin was also examined.

本文言語English
ページ(範囲)1030-1034
ページ数5
ジャーナルChemical and Pharmaceutical Bulletin
41
6
DOI
出版ステータスPublished - 1993
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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