Involvement of glutamate release in substance P-induced phase delays of suprachiasmatic neuron activity rhythm in vitro

Toshiyuki Hamada, Shiro Yamanouchi, Akihito Watanabe, Shigenobu Shibata*, Shigenori Watanabe

*この研究の対応する著者

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The suprachiasmatic nucleus (SCN) has been identified as a mammalian circadian rhythm clock. Treatment with substance P (SP) at zeitgeber time 13- 14 produced phase delays of circadian rhythm in spontaneous neural activity in SCN neurons in vitro. SP-induced phase delays are blocked by treatment with not only SP receptor antagonist, spantide, but N-methyl-D-aspartate receptor antagonist, MK-801. In the biochemical experiment, we demonstrated that SP-induced glutamate release from the SCN slices was observed by the high-performance liquid chromatography assay. The present results suggest that glutamate release may be involved in SP-induced phase delays.

本文言語English
ページ(範囲)190-193
ページ数4
ジャーナルBrain Research
836
1-2
DOI
出版ステータスPublished - 1999 7月 31

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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