Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Takao Shimazoe; Shigenobu Shibata; Shin Ichi Yatsugi; Showa Ueki

doi:10.1248/bpb1978.11.137

Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

Takao Shimazoe, Shigenobu Shibata, Shin Ichi Yatsugi, Showa Ueki

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

A forced swimming test proposed by Porsolt¹⁾ is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala le-sioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.

本文言語	English
ページ（範囲）	137-139
ページ数	3
ジャーナル	journal of pharmacobio-dynamics
巻	11
号	2
DOI	https://doi.org/10.1248/bpb1978.11.137
出版ステータス	Published - 1988 2 1
外部発表	はい

ASJC Scopus subject areas

薬理学

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10.1248/bpb1978.11.137

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Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test

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