Involvement of the suprachiasmatic nucleus in body temperature modulation by food deprivation in rats

Su Liu, Xiao Ming Chen, Tamae Yoda, Kei Nagashima, Yutaka Fukuda, Kazuyuki Kanosue*

*この研究の対応する著者

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Recently we found that food-deprived rats kept under a light-dark cycle showed a progressive reduction in body temperature during the light phase on each subsequent day while body temperature in the dark phase did not differ from baseline values. In this study, we investigated the effect of lesioning the hypothalamic suprachiasmatic nucleus (SCN) on body temperature modulation by food deprivation. In the SCN-lesioned rats in which daily rhythms of body temperature and activity were abolished, body temperature was unchanged by food deprivation. We also examined the effect of food deprivation on the daily changes in Fos expression in the SCN. Under normal fed conditions the number of SCN cells expressing Fos is high during the day and low at night. Food deprivation attenuated the amplitude of this daily change in Fos expression in the SCN. This tendency was prominent in the dorsal part of the SCN, while the ventral part showed no effect of food deprivation. These findings suggest that the SCN plays some role in body temperature modulation due to food deprivation.

本文言語English
ページ(範囲)26-36
ページ数11
ジャーナルBrain Research
929
1
DOI
出版ステータスPublished - 2002 3月 1
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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