Iodine-Catalyzed Synthesis of Chiral 4-Imidazolidinones Using α-Amino Acid Derivatives via Dehydrogenative N-H/C(sp3)-H Coupling

Kyalo Stephen Kanyiva*, Marina Tane, Takanori Shibata

*この研究の対応する著者

研究成果査読

12 被引用数 (Scopus)

抄録

An efficient method for the asymmetric synthesis of 4-imidazolidinones via an iodine-catalyzed intramolecular N-H/C(sp3)-H activation of readily available and abundant feedstocks, amino acids, and amines is described. The reaction proceeded under visible light irradiation to afford a variety of 4-imidazolidinone derivatives under mild conditions in moderate to excellent yields. Secondary and tertiary C(sp3)-H bonds were aminated, and various functional groups were tolerated.

本文言語English
ページ(範囲)12773-12783
ページ数11
ジャーナルJournal of Organic Chemistry
84
20
DOI
出版ステータスPublished - 2019 10 18

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

「Iodine-Catalyzed Synthesis of Chiral 4-Imidazolidinones Using α-Amino Acid Derivatives via Dehydrogenative N-H/C(sp<sup>3</sup>)-H Coupling」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル