Ir-Catalyzed Enantioselective Intra- and Intermolecular Formal C−H Conjugate Addition to β-Substituted α,β-Unsaturated Esters

Takanori Shibata*, Hisaki Kurita, Sahoko Onoda, Kyalo Stephen Kanyiva

*この研究の対応する著者

研究成果: Article査読

20 被引用数 (Scopus)

抄録

An enantioselective intramolecular formal C−H conjugate addition of 4-methyl 1-aryl 2-methylfumarates proceeded using a chiral iridium catalyst. A benzoylamide group served as a directing group, and chiral γ-lactones with a quaternary all-carbon stereogenic center were obtained with up to excellent ee. In the intermolecular reaction of N-arylbenzamides with β-substituted acrylates, C−H bond activation selectively occurred at the ortho-position of carbonyl groups, and highly enantioselective formal C−H conjugate addition proceeded.

本文言語English
ページ(範囲)1411-1418
ページ数8
ジャーナルAsian Journal of Organic Chemistry
7
7
DOI
出版ステータスPublished - 2018 7月

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

「Ir-Catalyzed Enantioselective Intra- and Intermolecular Formal C−H Conjugate Addition to β-Substituted α,β-Unsaturated Esters」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル