Iridium-catalyzed consecutive and enantioselective [2+2+2] cycloaddition of tetraynes and hexaynes for the construction of an axially chiral biaryl system

Takanori Shibata*, Shiho Yoshida, Yoshikazu Arai, Maiko Otsuka, Kohei Endo

*この研究の対応する著者

研究成果: Article査読

50 被引用数 (Scopus)

抄録

A chiral iridium complex catalyzed a consecutive and enantioselective [2+2+2] cycloaddition of polyynes to give axially chiral compounds. Intermolecular reaction of tetraynes, possessing aryl groups on their termini, with protected but-2-yne-1,4-diols gave C2-symmetrical quateraryl compounds. Intramolecular reaction of hexaynes, possessing aryl or alkyl groups on their termini gave C2-symmetrical biaryl compounds. The catalytic synthesis of a pentacene derivative with axial chiralities is also discussed.

本文言語English
ページ(範囲)821-830
ページ数10
ジャーナルTetrahedron
64
5
DOI
出版ステータスPublished - 2008 1月 28

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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