Iridium-catalyzed intramolecular enantioselective c-h alkylation at the C-2 position of N-alkenylindoles

Takanori Shibata, Naoto Ryu, Hideaki Takano

    研究成果: Article査読

    45 被引用数 (Scopus)

    抄録

    Intramolecular enantioselective alkylation of N-alkenylindoles proceeded via C-H bond cleavage at the C-2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C-3 position of the indoles operated as effective directing groups, and chiral 1-substituted-2,3-dihydro-1H-pyrrolo[1,2-a]indoles were obtained in high yield with excellent ee.

    本文言語English
    ページ(範囲)1131-1135
    ページ数5
    ジャーナルAdvanced Synthesis and Catalysis
    357
    6
    DOI
    出版ステータスPublished - 2015 4 13

    ASJC Scopus subject areas

    • Catalysis
    • Organic Chemistry

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