Iridium complex-catalyzed highly enantio- and diastereoselective [2+2+2] cycloaddition for the synthesis of axially chiral teraryl compounds

Takanori Shibata*, Takayoshi Fujimoto, Kazuhisa Yokota, Kentaro Takagi

*この研究の対応する著者

研究成果: Article査読

186 被引用数 (Scopus)

抄録

An asymmetric [2+2+2] cycloaddition of an α,ω-diyne, possessing ortho-substituted aryl groups on its terminus, and a monoalkyne with oxygen functionalities gave various axially chiral teraryl compounds. The coupling proceeded with extremely high enantio- (>99.5% ee) and diastereoselectivities (dl/meso = >95/5) when catalyzed by an iridium-chiral phosphine complex. As the products were readily transformed into diol compounds by deprotection without racemization, the present procedure provides access to a new chiral pool of diol compounds with C2 symmetry.

本文言語English
ページ(範囲)8382-8383
ページ数2
ジャーナルJournal of the American Chemical Society
126
27
DOI
出版ステータスPublished - 2004 7月 14

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

「Iridium complex-catalyzed highly enantio- and diastereoselective [2+2+2] cycloaddition for the synthesis of axially chiral teraryl compounds」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル