Is a sex-determining gene(s) necessary for sex-determination in amphibians? Steroid hormones may be the key factor

M. Nakamura*

*この研究の対応する著者

    研究成果: Article査読

    25 被引用数 (Scopus)

    抄録

    Amphibians have 2 genetic sex-determining systems, one with male (XX/XY) and one with female (ZZ/ZW) heterogamety. While the ancestral state of sex-determination is thought to be female heterogamety, male and female heterogametic types were probably once interchangeable. The Japanese frog Rana rugosa has both XX/XY and ZZ/ZW systems within a single species in certain local populations. However, steroid hormones can alter the phenotypic sex epigenetically. In R. rugosa, steroidogenic enzyme expression starts before sex-determination in the indifferent gonad, and these enzymes become active in both male and female tadpoles. Androgens are produced in the indifferent gonad of male tadpoles at high levels, whereas estrogens are synthesized in females. In this regard, the observed enhanced expression of the hormone-metabolizing genes, CYP19 in the female gonad and CYP17 in males, may be crucial for sex-determination. Moreover, with FSH known to increase estrogen synthesis in the vertebrate ovary, observed upregulation of FSH receptor (FSHR) expression in the indifferent gonad of female tadpoles is intriguing. These data suggest that steroid hormones could be crucial for sex-determination in R. rugosa, with the consequence that upregulation of CYP19 and FSHR expression is necessary for female and CYP17 for male sex-determination.

    本文言語English
    ページ(範囲)104-114
    ページ数11
    ジャーナルSexual Development
    7
    1-3
    DOI
    出版ステータスPublished - 2012 12

    ASJC Scopus subject areas

    • 発生生物学
    • 胎生学
    • 内分泌学、糖尿病および代謝内科学

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