Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility?

Asako Miyaki, Seiji Maeda*, Mutsuko Yoshizawa, Maiko Misono, Hiroyuki Sasai, Nobutake Shimojo, Kiyoji Tanaka, Ryuichi Ajisaka

*この研究の対応する著者

研究成果: Article査読

34 被引用数 (Scopus)

抄録

Aim: Obesity is a strong risk factor for cardiovascular morbidity and mortality. In addition, decreased central arterial distensibility is recognized as an independent risk factor for cardiovascular disease (CVD). Obese subjects exhibit low arterial distensibillity; however, the mechanism responsible for the decrease in arterial distensibility in obese subjects has not yet been elucidated. Pentraxin 3 (PTX3), a recently identified member of the pentraxin family of proteins, is produced in areas of atherosclerosis. A recent study has revealed that the PTX3 level may indicate the vascular inflammatory status. The aim of this study was to investigate plasma PTX3 concentrations and arterial distensibility in obese subjects. Methods: Eleven obese men (age: 44±2 years, body mass index [BMI]: 32±1 kg/m2) and 14 nonobese men (age: 42±2 years, BMI: 26±1 kg/m2) participated in this study. We measured arterial compliance (using simultaneous B-mode ultrasound and arterial applanation tonometry of the common carotid artery); β-stiffness index, an index of arterial compliance adjusted for distending pressure; and plasma PTX3 concentrations. Results: Arterial compliance was significantly lower and the β -stiffness index was significantly higher in obese men than in non-obese men. Plasma PTX3 concentration was markedly higher in obese than non-obese men. Conclusions: Obese men have lower arterial distensibility and higher circulating PTX3 levels than non-obese men; therefore, higher PTX3 levels and decreased arterial distensibility coexist in obese men. The high PTX3 concentrations in obese men may be involved in the mechanism underlying the obesity-induced decrease in arterial distensibility.

本文言語English
ページ(範囲)278-284
ページ数7
ジャーナルJournal of Atherosclerosis and Thrombosis
17
3
DOI
出版ステータスPublished - 2010
外部発表はい

ASJC Scopus subject areas

  • 内科学
  • 循環器および心血管医学
  • 生化学、医学

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